Research / Unapproved

Substance P: Research Status and Trial Data

Drafted by an automated content engine from FDA, PubChem, ClinicalTrials.gov, NIH DSLD, and Open Beauty Facts data.

Molecular formula	C63H98N18O13S
Molecular weight	1347.6 g/mol
Registered trials	1138
PubChem CID	36511

What Substance P Is

Substance P is a neuropeptide with the molecular formula C63H98N18O13S and a molecular weight of about 1,347.6 (PubChem CID 36511). It has no FDA-approved label, brand name, or approved indication. Any use outside of registered research settings falls outside current regulatory status.

Trial Footprint

Substance P and related pathways appear across 1,138 registered clinical trials. The available trial sample includes studies that are not specific to substance P itself but reference related targets, such as a completed Phase 3 trial of tradipitant in gastroparesis (NCT04028492), a completed Phase 3 pediatric leukemia chemotherapy trial (NCT00005585), and a completed Phase 2 trial of dasatinib in prostate cancer (NCT00385580). These entries reflect the breadth of the registered trial landscape rather than dedicated substance P efficacy data.

FAQ

Is substance P an FDA-approved drug?

No. Substance P does not have an FDA-approved label, brand name, or approved indication. It is classified as an unapproved research compound.

What is substance P chemically?

Substance P is a neuropeptide with the molecular formula C63H98N18O13S and a molecular weight of approximately 1,347.6. It is catalogued in PubChem under CID 36511.

How many clinical trials involve substance P?

There are 1,138 registered clinical trials associated with substance P and its related research pathways. The sample of available trials includes studies of related compounds and targets rather than substance P alone.

Does the trial data show that substance P works for any condition?

No. The trial sample provided reflects registration counts and related research activity, not evidence of efficacy for substance P itself. No approved-use or benefit claims can be made from this data.

Are there reported side effects for substance P?

No side effect reporting data is available for substance P in this dataset, since no approved label or FAERS data exists for it.

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Sources: PubChem ClinicalTrials.gov

Updated 2026-08-10