Approved

Retatrutide: Research Status, Trials, and What Is Known

Registered trials34

Many people searching for retatrutide want to know whether it is an approved medication and what stage its research has reached. As of the most recent data, retatrutide does not have an FDA-approved label.

What retatrutide is

Retatrutide, also known by the development code LY3437943, is a compound currently under clinical investigation. No approved product label, brand name, or FDA-sanctioned indication exists for it at this time.

Trial footprint

There are 34 registered clinical trials involving retatrutide. Sampled studies include a completed Phase 1 trial examining retatrutide's effect on metoprolol pharmacokinetics in healthy participants. Two Phase 3 trials are listed as active but not recruiting: one evaluating retatrutide for maintenance of weight reduction in individuals with obesity, and TRIUMPH-Outcomes, which is examining cardiovascular and kidney outcomes in adults living with obesity. These trials reflect ongoing investigation and do not establish approved uses or confirmed benefits.

FAQ

Is retatrutide FDA-approved?
No, retatrutide does not currently have an FDA-approved label or indication. It remains under clinical investigation.
What conditions is retatrutide being studied for?
Registered trials include research on weight reduction maintenance in individuals with obesity and a study on cardiovascular and kidney outcomes in adults with obesity. A pharmacokinetic interaction study with metoprolol has also been completed.
How many clinical trials involve retatrutide?
There are 34 registered clinical trials involving retatrutide as of the latest available data.
What is LY3437943?
LY3437943 is the development code used for retatrutide in clinical research and trial registries.
Are there known side effects of retatrutide?
No side effect report data is currently available for retatrutide in this summary. Because it lacks an approved label, no official safety profile has been established.
This page is an editorial information resource. It does not sell, prescribe, or recommend any medication. Content is editorial information, not medical advice. Talk to your doctor before any treatment decision.

Sources: ClinicalTrials.gov DailyMed

Updated 2026-09-19