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Research / Unapproved

MK-677 (Ibutamoren): Research Status Overview

Drafted by an automated content engine from FDA, PubChem, ClinicalTrials.gov, NIH DSLD, and Open Beauty Facts data.

Molecular formulaC28H40N4O8S2
Molecular weight624.8 g/mol
Registered trials8
PubChem CID6450830

What MK-677 Is

MK-677, known by the research name ibutamoren, is a synthetic compound with the molecular formula C28H40N4O8S2 and a molecular weight of about 624.8 g/mol (PubChem CID 6450830). It has no FDA-approved label, no approved brand name, and no approved medical indication. Any use outside of registered research settings falls outside its current regulatory status.

Trial Footprint

Eight trials involving ibutamoren are registered in a public clinical trials database. One recruiting study is examining an oral formulation referred to as LUM-201 in children with growth hormone deficiency. A completed study looked at ibutamoren's relationship to nonalcoholic fatty liver disease, and a separate study in post-hip-fracture patients with sarcopenia was terminated before completion. These studies reflect ongoing research interest rather than any established clinical benefit.

FAQ

What is MK-677?
MK-677, also called ibutamoren, is a research compound with the molecular formula C28H40N4O8S2 and a molecular weight of about 624.8 g/mol. It is tracked under PubChem CID 6450830. It has not been approved by the FDA for any use.
Is MK-677 approved for any medical use?
No. There is no FDA-approved label, brand name, or approved indication for MK-677. It remains classified as an unapproved research compound.
What clinical trials are studying MK-677?
Eight trials involving ibutamoren are registered publicly. These include a recruiting study of an oral formulation called LUM-201 in children with growth hormone deficiency, a completed study on nonalcoholic fatty liver disease, and a terminated study on sarcopenia after hip fracture.
Is there safety data available for MK-677?
No adverse event report data was available for MK-677 at the time this overview was compiled. This reflects a gap in currently accessible reporting databases, not a confirmation of safety.
This page is an editorial information resource. It does not sell, prescribe, or recommend any medication. Content is editorial information, not medical advice. Talk to your doctor before any treatment decision.

Sources: PubChem CID 6450830 ClinicalTrials.gov NCT06948214 ClinicalTrials.gov NCT05364684 ClinicalTrials.gov NCT00128115

Updated 2026-08-03