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Research / Unapproved

MK-677 (Ibutamoren): Research Status and Clinical Trial Data

Molecular formulaC28H40N4O8S2
Molecular weight624.8 g/mol
Registered trials8
PubChem CID6450830

What MK-677 Is

MK-677, also known as ibutamoren, is a synthetic compound with the molecular formula C28H40N4O8S2. It has no FDA-approved label and is not approved for any medical use in humans. No drug label, indication, or mechanism-of-action statement is on file for this compound in the data reviewed here. It is classified as an unapproved research compound, meaning any use outside of registered clinical trials falls outside regulatory oversight.

Clinical Trial Footprint

Eight trials involving MK-677 are registered. Among the studies on record, one phase 2 trial evaluated an oral growth hormone drug for fibromyalgia and was completed, while a separate phase 2 study looking at sarcopenia in post-hip fracture patients was terminated. A phase 3 trial referencing a related growth hormone deficiency program in children is currently listed as recruiting. These records reflect trial registration and status only, not confirmed outcomes or approved uses.

FAQ

Is MK-677 FDA-approved?
No. MK-677 (ibutamoren) has no FDA-approved label and is classified as an unapproved research compound. It is not approved for any medical condition in humans.
What is MK-677 studied for?
Registered trials have examined MK-677 in contexts such as fibromyalgia and sarcopenia following hip fracture. A phase 3 trial referencing a related growth hormone deficiency program in children is also listed. These are research studies and do not establish approved uses.
How many clinical trials have studied MK-677?
Eight trials involving MK-677 are registered as of the most recent data reviewed. Trial statuses vary, including completed, terminated, and recruiting studies.
Does research on MK-677 show it is safe or effective?
The available trial records only describe study design, phase, and status, not confirmed safety or efficacy conclusions. No side effect report data was available for MK-677 in this review.
What is the chemical identity of MK-677?
MK-677 (ibutamoren) has the molecular formula C28H40N4O8S2 and a molecular weight of 624.8. It is cataloged in PubChem under CID 6450830.
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Sources: PubChem ClinicalTrials.gov

Updated 2026-09-19